Margaret was the wife of Thomas Davies Giles. They had an infant daughter, Maria, who died in Chicago before the Giles family started traveling in the Bunker company. Margaret gave birth in mid-to-late-September and died. Her newborn daughter, Elizabeth, survived her mother, dying in late October on the trail. The Giles children were put under the care of Hannah Evans and Hannah's daughter, Ann Bowen Dee, both of whom were traveling in the 1856 Hunt wagon company.